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(S)-2-(Methoxydiphenylmethyl)pyrrolidine

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(S)-2-(Methoxydiphenylmethyl)pyrrolidine Basic information

Product Name:
(S)-2-(Methoxydiphenylmethyl)pyrrolidine
Synonyms:
  • (S)-2-(Methoxydiphenylmethyl)pyrrolidine
  • (S)-2-(MethoxydiphenylMethyl)pyrrolidine 95% (HPLC)
  • (2S)-2-[Diphenyl(methoxy)methyl]pyrrolidine
  • (2S)-2-[Diphenyl(methoxy)methyl]tetrahydropyrrole
  • -2-(Methoxydiphenylmethyl)
  • (2S)-2-(Methoxydiphenylmethyl)pyrrolidine
  • Pyrrolidine, 2-(methoxydiphenylmethyl)-, (2S)-
CAS:
118971-03-2
MF:
C18H21NO
MW:
267.37
Product Categories:
  • Asymmetric Synthesis
  • Chiral Catalysts, Ligands, and Reagents
  • Proline-Based Organocatalysts
Mol File:
118971-03-2.mol
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(S)-2-(Methoxydiphenylmethyl)pyrrolidine Chemical Properties

Boiling point:
368.7±32.0 °C(Predicted)
Density 
1.070±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in Dichloromethane, Ethyl Acetate
pka
10.09±0.10(Predicted)
form 
Oil
color 
Yellow
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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(S)-2-(Methoxydiphenylmethyl)pyrrolidine Usage And Synthesis

Uses

(S)-2-(Methoxydiphenylmethyl)pyrrolidine is a diphenylprolinol methyl ether, which can be used as a catalyst to synthesize:

  • Enantioselective ketones via intermolecular asymmetric Michael addition of aldehydes to nonactivated enones.
  • Stereoselective chiral bipyrazolidin-3-one derivatives by dipolar cycloaddition reaction of azomethine imines with α, β-unsaturated aldehydes.
  • Enantioenriched spiro nitrogen heterocycles via asymmetric nucleophilic epoxidation of α-ylideneoxindole esters.
  • Optically active secondary alcohols by asymmetric addition of Et2Zn to various aldehydes.

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Adamas Reagent, Ltd.
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