ETIROXATE Chemical Properties

Melting point:

149-1510C

Boiling point:

563.7±50.0 °C(Predicted)

Density 

2.321±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO, Methanol

form 

Solid

pka

6.89±0.25(Predicted)

color 

Tan

ETIROXATE Usage And Synthesis

Chemical Properties

Tan Solid

Originator

Skleronorm,Gruenenthal,W. Germany,1977

Uses

Derivative of thyroxine. Antilipemic.

Definition

ChEBI: Etiroxate is an aromatic ether.

Manufacturing Process

7.91 g of α-methyl thyroxine are suspended in 150 cc of ethanol. While heating, the solution is saturated with dry hydrogen chloride. Thereafter, the solvent is distilled off at reduced pressure. The residue is dissolved in a mixture of ethanol and water (1:1). Adding a 5% solution of sodium hydrogen carbonate in water, the ethyl ester of α-methyl thyroxine precipitates; melting point: 156°C to 157°C after recrystallization from ethanol. The yield is 6.05 g, i.e., 74% of the theoretical yield.

Therapeutic Function

Antihyperlipoproteinemic

ETIROXATE(17365-01-4)Related Product Information

• 2-Amino-2-methyl-propionic acid ethyl ester hydrochloride
• 3,5-DIIODO-DL-THYRONINE
• 1-METHOXY-3,5-DIIODOBENZENE
• ETHYL (S)-2-AMINO-2-METHYLBUTYRATE
• 3,3',5-TRIIODOTHYROPROPIONIC ACID
• 3 5-DIIODOTHYROPROPIONIC ACID
• DL-ALPHA-METHYLTYROSINE
• DL-THYROXINE
• 2 6-DIIODOHYDROQUINONE
• ETIROXATE