PARA-TOPOLIN RIBOSIDE 99% (HPLC) Chemical Properties

Melting point:

201-204 °C(Solv: methanol (67-56-1); chloroform (67-66-3))

Boiling point:

753.2±70.0 °C(Predicted)

Density 

1.71

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Sonicated)

pka

9.72±0.15(Predicted)

form 

Solid

color 

White to Off-White

PARA-TOPOLIN RIBOSIDE 99% (HPLC) Usage And Synthesis

Uses

N6-(4-Hydroxybenzyl)adenosine is am endogenous compound extracted from G. elata for research interest for its potential sedative and hypnotic activity, as well as a neuroprotective and therapeutic agent for preventing and treating neurodegenerative disease.

Biological Activity

N6-(4-Hydroxybenzyl) adenine riboside (NHBA) is an orally available and brain penetrant active active ingredient of Gastrodia elata rhizomes used for the treatment of insomnia. N6-(4-Hydroxybenzyl) adenine riboside is an adenosine A2A receptor and the equilibrative nucleoside transporter 1 (ENT1) agonist. It exhibits sedative and hypnotic effects by binding to adenosine A1 and A2A receptors in mice. N6-(4-Hydroxybenzyl) adenine riboside exerted a therapeutic effect on HD transgenic mouse by decreasing protein level of polyglutamine-expanded huntingtin in the striatum.