7-bromoindolin-2-one Chemical Properties

Melting point:

194-200°C

Boiling point:

358.8±42.0 °C(Predicted)

Density 

1.666±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

13.22±0.20(Predicted)

color 

White to Light yellow to Light orange

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2933790090

7-bromoindolin-2-one Usage And Synthesis

Preparation

STEP A: Preparation of 7-chloro-3-hydrazono-oxindole. A solution of 25.0 g of 7-chloro-isatin in 250 ml of ethanol is refluxed for 24 hours, cooled, and precipitate recovered by filtering and washed once with ethanol and twice with pentane to obtain 7-chloro-3-hydrazono oxindole, m.p. 217-219℃. (decomp.).  STEP B: Preparation of 7-chloro-oxindole. To a solution of sodium ethoxide prepared by heating 5.5 g of sodium in 200 ml. of ethanol at 70°℃. is added 17 g of 7-chloro-3-hydrazono-oxindole over a period of 3.5 hours, and the resulting solution is heated at 70℃. for 24 hours. The solvent is evaporated in vacuo, the residue dissolved in water, acidified with 6 N-hydro chloric acid and the resulting precipitate recovered by filtering, washed three times with water, dried by suc tion and crystallized from methylene chloride/ether to obtain 7-chlorooxindole, 28-220℃.

7-bromoindolin-2-one(320734-35-8)Related Product Information

• 7-Bromoisoquinoline
• 1H-Indole-3-carbonitrile, 7-broMo-
• 7-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
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• Ziprasidone hydrochloride monohydrate
• 5-Chloro-1-indanone
• 5-[2-[4-(1,2-benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one mesilate
• 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indol-2-one ,5-CHLOROACETYL-6-CHLOROOXINDOLE
• 6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE,6-CHLOROOXINDOLE
• 7-BROMO-1H-INDOLE-2,3-DIONE
• 7-BROMO-5-METHYL-1H-INDOLE-2,3-DIONE
• 7-bromoindolin-2-one
• 5-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE,5-CHLOROOXINDOLE
• 6-Chloro-5-(2-chloroethyl)oxindole
• 4-CHLOROOXINDOLE,4-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE
• CHEMBRDG-BB 5226017
• 4-[2-(BENZOYLOXY)ETHYL]-3-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE
• 5,7-DIBROMO-1,3-DIHYDRO-INDOL-2-ONE