Sodium orthovanadate Chemical Properties

Melting point:

850-866 °C(lit.)

storage temp. 

Sealed in dry,Room Temperature

solubility 

H₂O: soluble

form 

Solid

color 

off-white

Water Solubility 

soluble

Exposure limits

NIOSH: Ceiling 0.05 mg/m3

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

13721-39-6(CAS DataBase Reference)

EPA Substance Registry System

Sodium vanadium oxide (Na3VO4) (13721-39-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

22-36

RIDADR 

UN3285

WGK Germany 

3

RTECS 

YW1120000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

28419030

MSDS

• Language:English Provider:Sodium orthovanadate
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• Language:English Provider:ACROS
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Sodium orthovanadate Usage And Synthesis

Chemical Properties

It forms colourless hexagonal columnar crystals that are soluble in water but insoluble in ethanol.

Uses

Sodium orthovanadate (Na3VO4) can be used as a metal precursor in the synthesis of:
Vanadium-MCM-48 (V-MCM-48) by anion-exchange method. V-MCM-48 is used as a catalyst in oxidation of styrene to benzaldehyde.
Nanorods of vanadium oxide particles by glycothermal method.
Yttrium vanadate (YVO4) doped with colloidal europium.

Uses

Sodium Orthovanadate is an inhibitor of several phosphatases and kinases. General inhibitor of tyrosine phosphatases, a large family of enzymes that catalyze the removal of phosphate groups from tyrosine residues.

Definition

ChEBI: Trisodium vanadate is an inorganic sodium salt of formula Na3VO4 containing the tetrahedral VO4(3-) It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, a radiation protective agent, an apoptosis inducer and an antineoplastic agent. It contains a vanadate(3-).

Preparation

Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:
V2O5 + 6 NaOH → 2 Na3VO4 + 3 H2O
The salt features tetrahedral VO3-4 anion centers linked to octahedral Na+ cation sites.

Hazard

Poison by ingestion.

Biological Activity

Inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases.

Biochem/physiol Actions

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25

Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of VOx and NazO. See also VANADIUM COMPOUNDS.

storage

Store at RT

Sodium orthovanadate(13721-39-6)Related Product Information

• Vanadium(V) oxide
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• SODIUM PYROVANADATE
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• Sodium orthovanadate