Lysicamine
Lysicamine Basic information
- Product Name:
- Lysicamine
- Synonyms:
-
- Lysicamine
- 1,2-Dimethoxy-7H-dibenzo[de,g]quinolin-7-one
- Oxonuciferine
- 7H-Dibenzo[de,g]quinolin-7-one, 1,2-dimethoxy-
- CAS:
- 15444-20-9
- MF:
- C18H13NO3
- MW:
- 291.3
- Mol File:
- 15444-20-9.mol
Lysicamine Chemical Properties
- Melting point:
- 210-1 °c (dec.).
- Boiling point:
- 509.4±45.0 °C(Predicted)
- Density
- 1.323±0.06 g/cm3(Predicted)
- pka
- 2.67±0.20(Predicted)
Lysicamine Usage And Synthesis
Description
This oxodibenzoquinoline alkaloid occurs in Lysichiton camtschatcense Schott var. japonicum Makino. Being a fully conjugated molecule, the alkaloid is coloured, yielding yellow needles when crystallized from EtOH. The ultraviolet spectrum in neutral solution (EtOH) has absorption maxima at 235, 270, 307 and 400 mil. In acid solution (EtOH-O.l N/HCl), the absorption maxima occur at 249,276,306 and 453 mil. The structure has been established by synthesis as 1 :2-dimethoxy-7-oxodibenzo[de, gj quinoline.
Uses
Lyscamine has shown to have cytotoxicity against various human cancer cells. It can also be enriched using response surface method and adsorption on macroporous resin.
Definition
ChEBI: A natural product found in Annona glabra.
References
Katsui et al., Tetrahedron Lett., 6257 (1966)
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