Basic information Safety Supplier Related

Aligeron

Basic information Safety Supplier Related

Aligeron Basic information

Product Name:
Aligeron
Synonyms:
  • Aligeron
  • Piperazine, 1-(diphenylmethyl)-4-(2-propen-1-yl)-
CAS:
70713-45-0
MF:
C20H24N2
MW:
292.424
Mol File:
70713-45-0.mol
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Aligeron Chemical Properties

Boiling point:
390.6±37.0 °C(Predicted)
Density 
1.044±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
6.79±0.10(Predicted)
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Aligeron Usage And Synthesis

Uses

Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.

in vivo

In hypoventilation hypoxia, aligeron (5 mg/kg i.v.) and cinnarizine increase cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions aligeron shows a protective effect manifested in a decrease of the degree and duration of the depression[2].

References

[1] Miyares K, et al. Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli. Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):473-6. PMID:4079597
[2] Dimov S, et al. Effect of aligeron and cinnarizine in models of general and local depression of the cortical bioelectrical activity in cats. Methods Find Exp Clin Pharmacol. 1983;5(2):89-95. PMID:6308367

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