Benzeneacetic acid, 2,5-dichloro- Chemical Properties

Melting point:

105-107℃

Boiling point:

322.5±27.0 °C(Predicted)

Density 

1.456

storage temp. 

Sealed in dry,Room Temperature

pka

3.87±0.10(Predicted)

Appearance

White to off-white Solid

Benzeneacetic acid, 2,5-dichloro- Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2,5-dichlorophenylacetic acid from 2,5-dichlorophenylacetonitrile was as follows: concentrated sulfuric acid (8 mL) was added dropwise to a stirring solution of 2-(2,5-dichlorophenyl)acetonitrile (700 mg, 3.76 mmol, 1.00 equiv.) in water (6 mL). The reaction mixture was stirred in an oil bath at 110 °C for 3 hours. Upon completion of the reaction, the reaction solution was diluted with distilled water (100 mL) and subsequently extracted with dichloromethane (3 x 50 mL). The organic layers were combined, washed with saturated saline (3 x 100 mL) and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give 700 mg (91% yield) of 2,5-dichlorophenylacetic acid as a white solid.

References

[1] Patent: WO2013/96771, 2013, A1. Location in patent: Page/Page column 165
[2] Phytochemistry (Elsevier), 1988, vol. 27, # l, p. 51 - 72
[3] Patent: WO2008/91594, 2008, A2. Location in patent: Page/Page column 73
[4] Patent: WO2007/14290, 2007, A2. Location in patent: Page/Page column 56

Benzeneacetic acid, 2,5-dichloro-(5398-79-8)Related Product Information

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