aspidin BB
aspidin BB Basic information
- Product Name:
- aspidin BB
- Synonyms:
-
- aspidin BB
- 2-[[2,6-Dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)-2,5-cyclohexadien-1-one
- 2,5-Cyclohexadien-1-one, 2-[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)-
- CAS:
- 584-28-1
- MF:
- C25H32O8
- MW:
- 460.52
- Mol File:
- 584-28-1.mol
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aspidin BB Chemical Properties
- Melting point:
- 124-125°
- Boiling point:
- 661.2±55.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- pka
- 4.50±1.00(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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aspidin BB Usage And Synthesis
Uses
Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2].
Definition
ChEBI: Aspidin is a carboxylic ester. It is functionally related to a phloroglucinol.
IC 50
Bcl-2; Bax; Caspase-3
References
[1] Sun Y, et al. Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells. Chem Biol Interact. 2013 Jul 5;204(2):88-97. DOI:10.1016/j.cbi.2013.04.008
[2] Chen NH, et al. Drychampones A-C: Three Meroterpenoids from Dryopteris championii. J Org Chem. 2016 Oct 7;81(19):9443-9448. DOI:10.1021/acs.joc.6b01720