YM 16638
YM 16638 Basic information
- Product Name:
- YM 16638
- Synonyms:
-
- YM 16638
- [[5-[[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl]thio]-1,3,4-thiadiazol-2-yl]thio]acetic acid
- YM-638
- 2-[[5-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetic acid
- Acetic acid, 2-[[5-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl]thio]-1,3,4-thiadiazol-2-yl]thio]-
- YM 638|||YM-16638|||YM16638
- CAS:
- 104073-72-5
- MF:
- C18H22N2O5S3
- MW:
- 442.57
- Mol File:
- 104073-72-5.mol
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YM 16638 Chemical Properties
- Melting point:
- 129-130 °C
- Boiling point:
- 682.6±65.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- pka
- 2.87±0.10(Predicted)
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YM 16638 Usage And Synthesis
Uses
YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC4, LTD4, and LTE4 in guinea pig trachea, with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep[1].
References
[1] Tomioka K, et al. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):43-7. DOI:10.1016/0952-3278(89)90161-0
YM 16638Supplier
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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Shanghai Dexuan Pharmaceutical Technology Co., Ltd
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- 1701086315
- dexuanpharma@126.com
Shanghai Yifei Biotechnology Co. , Ltd.
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- 021-65675885 18964387627
- customer_service@efebio.com
TargetMol Chemicals Inc.
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- 15002134094
- marketing@targetmol.cn
Sangon Biotech (Shanghai) Co.,Ltd.
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- 400-821-026
- Sales@sangon.com