BIBW 22 Usage And Synthesis

Description

Bibw 22 is a bifunctional modulator of P-glycoprotein and nucleoside transport; may be useful as a modulator of combination chemotherapy involving compounds affected by multidrug resistance.

Uses

BIBW 22 (BIBW22BS) is a dipyridamole analogue. BIBW 22 is a potent bifunctional modulator that affects p-glycoprotein and nucleoside transport in tumor cells[1].

References

[1] Chen HX, et al. BIBW 22, a dipyridamole analogue, acts as a bifunctional modulator on tumor cells by influencing both P-glycoprotein and nucleoside transport. Cancer Res. 1993 May 1;53(9):1974-7. PMID:8097671

BIBW 22(137694-16-7)Related Product Information

• (R)-2-Methyl-morpholine
• Triamterene
• Dimethylmorpholine
• (S)-2-Methyl-morpholine
• 2,4-BIS(DIMETHYLAMINO)-PYRIMIDINE
• BIBW 22