SK&F 89976-A
SK&F 89976-A Basic information
- Product Name:
- SK&F 89976-A
- Synonyms:
-
- 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid
- SKF-89976
- 3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-buten-1-yl)-
- CAS:
- 85375-85-5
- MF:
- C22H25NO2
- MW:
- 335.44
- Mol File:
- 85375-85-5.mol
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SK&F 89976-A Chemical Properties
- Boiling point:
- 531.4±50.0 °C(Predicted)
- Density
- 1.121±0.06 g/cm3(Predicted)
- pka
- 3.87±0.20(Predicted)
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SK&F 89976-A Usage And Synthesis
Description
SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.
Definition
ChEBI: 1-(4,4-diphenylbut-3-enyl)-3-piperidinecarboxylic acid is a diarylmethane.