phendioxan
phendioxan Basic information
- Product Name:
- phendioxan
- Synonyms:
-
- phendioxan
- (2R)-2,3-Dihydro-3β-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-2α-phenyl-1,4-benzodioxin
- 1,4-Benzodioxin-2-methanamine, N-[2-(2,6-dimethoxyphenoxy)ethyl]-2,3-dihydro-3-phenyl-, (2R,3R)-rel-
- CAS:
- 130905-04-3
- MF:
- C25H27NO5
- MW:
- 421.49
- Mol File:
- 130905-04-3.mol
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phendioxan Chemical Properties
- Boiling point:
- 559.0±50.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- pka
- 7.61±0.20(Predicted)
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phendioxan Usage And Synthesis
Uses
Phendioxan is a compound with binding activity at the α(1)-adrenaline receptor subtype. The facilitated membrane diffusion of phendioxan is thought to be associated with improved α(1d)-AR affinity. Docking simulations of phendioxan at biological targets supported the stoichiometric analysis and revealed the importance of polar, electrostatic, hydrophobic, and shape effects of its phenoxy terminal orthogonal substituents on ligand binding[1].
References
[1] Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel α1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and α1d computational study