2,6-Dichloro-4-methyl-3-nitropyridine Chemical Properties

Boiling point:

317 °C

Density 

1.537

Flash point:

145 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-4.96±0.10(Predicted)

form 

solid

color 

Light yellow

InChI

InChI=1S/C6H4Cl2N2O2/c1-3-2-4(7)9-6(8)5(3)10(11)12/h2H,1H3

InChIKey

CMJNIYUZFQWYCK-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(Cl)=CC(C)=C1[N+]([O-])=O

Safety Information

HS Code 

2933399990

2,6-Dichloro-4-methyl-3-nitropyridine Usage And Synthesis

Uses

2,6-Dichloro-4-methyl-3-nitropyridine is used in preparation of imidazolopyridine derivatives as agricultural fungicides and insecticides.

Synthesis

Step 1: Synthesis of 2,6-dichloro-4-methyl-3-nitropyridine from 2,6-dichloro-4-methylpyridine 1.1 Suspend 2,6-dichloro-4-methylpyridine (1 g, 6.17 mmol) in trifluoroacetic anhydride (5 mL, 35.4 mmol) and cool to 0 °C. 1.2 Nitric acid (0.579 mL, 12.96 mmol) was slowly added dropwise to the above suspension at 0 °C. 1.3 After the dropwise addition was completed, the reaction mixture was stirred at room temperature for 18 hours. 1.4 The reaction mixture was slowly added to a pre-cooled aqueous solution (8 mL) of sodium metabisulfite (1.183 g, 6.17 mmol) and stirring was continued for 2 hours at room temperature. 1.5 The pH of the reaction mixture was adjusted to 7 using 8N NaOH solution. 1.6 The reaction mixture was extracted twice with dichloromethane (CH2Cl2). 1.7 The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 2,6-dichloro-4-methyl-3-nitropyridine (1.187 g, 5.73 mmol, 93% yield) as a white solid. 1.8 Product identification: retention time (tR) 1.07 min (LC-MS 2); electrospray ionization mass spectrometry (ESI-MS): 208 [M + H]+ (LC-MS 2); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.39 (s, 3H), 7.90 (s, 1H).

References

[1] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 1033; 1034
[2] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 213; 214
[3] Patent: US2015/152108, 2015, A1. Location in patent: Paragraph 0323; 0324
[4] Patent: WO2016/79709, 2016, A1. Location in patent: Page/Page column 141
[5] Patent: WO2014/191894, 2014, A1. Location in patent: Page/Page column 199; 200

2,6-Dichloro-4-methyl-3-nitropyridine(60010-03-9)Related Product Information

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