7-methoxyindoline-2,3-dione Chemical Properties

Melting point:

240-242℃

Density 

1.346

storage temp. 

Sealed in dry,Room Temperature

pka

9.69±0.20(Predicted)

Appearance

Reddish brown to red Solid

Safety Information

HazardClass 

IRRITANT

HS Code 

2933998090

7-methoxyindoline-2,3-dione Usage And Synthesis

Uses

7-Methoxy-1H-indole-2,3-dione is one of the key intermediates of the EP3 receptor, which has a variety of biological functions, including digestion, the nervous system, renal reabsorption, uterine contraction activity, and inhibition of gastric acid secretion.

Synthesis

7-Methoxyisatin is synthesized in four steps. a) 4-Hydroxybenzaldehyde reacts with methyl iodide in DMSO and K2CO3 to give 4-methoxybenzaldehyde. b) 4-Methoxybenzaldehyde reacts with methyl azidoacetate in sodium methoxide/methanol to yield an azide intermediate. This intermediate is refluxed in boiling xylene to give methyl 6-methoxyindole-2-carboxylate. c) This ester is saponified by refluxing with NaOH/methanol. Acidification yields 6-methoxyindole-2-carboxylic acid. d) This acid reacts with ethyl N,N-dichlorocarbamate in aqueous acetic acid. Work-up gives 7-methoxy-1H-indole-2,3-dione.

7-methoxyindoline-2,3-dione(84575-27-9)Related Product Information

• 7-methoxyquinoline
• 4-CHLOROISATIN
• 7-Fluoroisatin
• 4,6-DIFLUOROINDOLINE-2,3-DIONE
• 7-Methoxy-1H-indole
• 7-METHOXY-ISOQUINOLINE
• 7-TRIFLUOROMETHOXY-ISATIN
• 4-CHLORO-7-METHOXY ISATIN
• 7-methoxyindoline-2,3-dione
• 4-Bromo-7-methoxyisatin
• 5,7-dimethoxyindoline-2,3-dione
• 5-chloro-4,7-dimethoxy-1H-indole-2,3-dione
• 7-ethoxy-1H-indole-2,3-dione
• 7-phenoxy-1H-indole-2,3-dione
• 4-chloro-5,7-dimethoxy-1H-indole-2,3-dione
• 2,2-Difluoro-8H-1,3-dioxa-8-aza- as-indacene-6,7-dione
• 7-propoxy-1H-indole-2,3-dione
• 5-chloro-7-methoxy-4-methyl-2,3-dihydro-1H-indole-2,3-dione