Z-PHE-LEU-GLU-PNA Chemical Properties

Boiling point:

1004.4±65.0 °C(Predicted)

Density 

1.304±0.06 g/cm3(Predicted)

pka

4.42±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

Z-Phe-Leu-{Glu-pNA}

Z-PHE-LEU-GLU-PNA Usage And Synthesis

Uses

Z-Phe-Leu-Glu-pNA is a chromogenic substrate for glutamyl endopeptidases. Z-Phe-Leu-Glu-pNA has been used as a synthetic substrate in the study of proteolytic enzymes, including trypsin treatment, subtilisin and chymotrypsin. Z-Phe-Leu-Glu-pNA plays an important role in hormone disorders such as prostate cancer and breast cancer[1][2].

References

[1] Wei Ye, et al. Characterization of the glutamate-specific endopeptidase from?Bacillus licheniformis?expressed in?Escherichia coli. J Biotechnol. 2013 Oct 10;168(1):40-5. DOI:10.1016/j.jbiotec.2013.08.009
[2] Wei Ye, et al. A new strategy for recovery of two peptides without Glu employing glutamate-specific endopeptidase from Bacillus licheniformis. Enzyme Microb Technol. 2014 Jan 10:54:25-31. DOI:10.1016/j.enzmictec.2013.09.013

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