4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester Chemical Properties

Melting point:

213-215 °C

Boiling point:

411.8±45.0 °C(Predicted)

Density 

1.256±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

11.16±0.70(Predicted)

4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester Usage And Synthesis

Uses

4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in Laboratory research and development process and chemical production process.

Synthesis

Substituted benzaldehyde (6.617×10-3mmol; 1.0 equiv.) is mixed with slightly excess equivalent of urea (6.749×10-3mmol; 1.02 equiv.) and ethyl acetoacetate (6.749×10-3mmol; 1.02 equiv.) in the presence of catalytic concentration 1.0×10-4mmol of our synthesized dimeric pyridinium salts along with dry MeCN at ambient reaction condition from 6-33 min. reaction condition. Yield: 92%

4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester(5948-71-0)Related Product Information

• SALOR-INT L202681-1EA
• ETHYL 6-(CHLOROMETHYL)-4-(4-CHLOROPHENYL)-2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
• ETHYL 6-(BROMOMETHYL)-4-(4-CHLOROPHENYL)-2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
• SALOR-INT L254142-1EA
• 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester