8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate Chemical Properties

Density 

1.38±0.1 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: soluble >10mg/mL

pka

8.24±0.70(Predicted)

form 

solid

color 

off-white

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate Usage And Synthesis

Uses

MRS 1754 acts as an adenosine receptor antagonist which displays bronchospasmolytic activity, applicable to treatments involving respiratory disorders.

Definition

ChEBI: N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide is an oxopurine.

Biological Activity

Selective adenosine A 2B receptor antagonist (K i values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA 2B , rA 1 , hA 1 , hA 2A , hA 3 and rA 2A receptors respectively).

Biochem/physiol Actions

MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.

storage

Desiccate at RT

8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate(264622-58-4)Related Product Information

• 1,3-DIETHYL-8-PHENYLXANTHINE
• 1,3-DIPROPYL-8-PHENYLXANTHINE
• 8-PHENYLTHEOPHYLLINE
• 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate