Cefcapene Pivoxil Hydrochloride
Cefcapene Pivoxil Hydrochloride Basic information
- Product Name:
- Cefcapene Pivoxil Hydrochloride
- Synonyms:
-
- (6R,7R)-(Pivaloyloxy)methyl 7-((Z)-2-(2-aminothiazol-4-yl)pent-2-enamido)-3-((carbamoyloxy)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride
- 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-(((2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R,7R)-
- 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R-(6alpha,7beta(Z)))-
- Cefcapinaxil hydrochloride
- Cefcapene Pivoxil Hydrochloride RS
- CAS:
- 147816-23-7
- MF:
- C23H30ClN5O8S2
- MW:
- 604.096
- Product Categories:
-
- Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 147816-23-7.mol
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Cefcapene Pivoxil Hydrochloride Chemical Properties
- Melting point:
- 158-164°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
- form
- Solid
- color
- White to Pale Beige
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Cefcapene Pivoxil Hydrochloride Usage And Synthesis
Chemical Properties
White to Off-White Solid
Uses
Antibacterial. Orally absorbed cephalosporin; ester prodrug of the active free acid metabolite, cefcapene.
in vivo
Cefcapene pivoxil hydrochloride (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, stimates peak antibiotic concentrations of 1 to 2 μg/ml?in the blood of mice from 30 to 120 min after intragastric administration[3].
| Animal Model: | Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109?CFU)[3] |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; 100mg/kg; 4 days |
| Result: | Was against?H. influenzae?colonization in mouse lung. |
IC 50
β-lactam
Cefcapene Pivoxil HydrochlorideSupplier
J & K SCIENTIFIC LTD.
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Shanghai TaoSu Biochemical Technology Co., Ltd.
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Shanghai Kewel Chemical Co., Ltd.
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