AC9-25
AC9-25 Basic information
- Product Name:
- AC9-25
- Synonyms:
-
- AC9-25
- L-Lysine, N2-acetyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-
- Ac9-25 TFA salt
- CAS:
- 284040-76-2
- MF:
- C99H143N23O33
- MW:
- 2183.33
- Mol File:
- 284040-76-2.mol
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AC9-25 Chemical Properties
- Boiling point:
- 2439.8±65.0 °C(Predicted)
- Density
- 1.354±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- pka
- 3.29±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in 20% acetonitrile / Water
- Sequence
- Ac-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys
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AC9-25 Usage And Synthesis
Uses
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR[1][2].
References
[1] Walther A, et al. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5(5):831-840. DOI:10.1016/s1097-2765(00)80323-8
[2] Karlsson J, et al. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol. 2005;78(3):762-771. DOI:10.1189/jlb.0305153
AC9-25Supplier
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