1-LINOLEOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE Chemical Properties

storage temp. 

Store at -20°C

solubility 

PBS (pH 7.2): 2 mg/ml

form 

Oil

color 

White to light yellow

1-LINOLEOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE Usage And Synthesis

Uses

Lysophosphatidylcholine 18:2 (1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC), a lysophospholipid, is a potential biomarker identified from insulin resistance (IR) polycystic ovary syndrome (PCOS). Low plasma Lysophosphatidylcholine 18:2 also has been shown to predict impaired glucose tolerance, insulin resistance, type 2 diabetes, coronary artery disease, and memory impairment[1][2].

Definition

ChEBI: 1-linoleoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine 18:2 in which the acyl group at position 1 is (9Z,12Z)-octadecadienoyl. It has a role as a mouse metabolite. It is a lysophosphatidylcholine(18:2/0:0) and a linoleoyl-sn-glycero-3-phosphocholine. It is functionally related to a linoleic acid.

Biological Activity

1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at the sn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1 Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2

IC 50

Human Endogenous Metabolite

References

1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, W.E., Beebe, K., Lawton, K.A., et al.α-Hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic populationPLoS One5(5)e10883(2010)

1-LINOLEOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE(22252-07-9)Related Product Information

• 1-LINOLEOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE
• 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE