ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Pyridine compound > Benzylpyridinium > 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Basic information
- Product Name:
- 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
- Synonyms:
-
- EVATANEPAG;CP-533536;CP 533536
- CP-533536;CP 533536;CP533536
- (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid
- Evatanepag (CP-533536)
- CS-2325
- 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
- CP-533536
- Evatanepag
- CAS:
- 223488-57-1
- MF:
- C25H28N2O5S
- MW:
- 468.57
- Mol File:
- 223488-57-1.mol
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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Chemical Properties
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:32.0(Max Conc. mg/mL);68.29(Max Conc. mM)
- form
- Solid
- color
- White to off-white
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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Usage And Synthesis
Uses
Evatanepag is an EP2 receptor selective prostaglandin E2 agonist that helps induce bone growth.
Definition
ChEBI: Evatanepag is a monocarboxylic acid.
in vivo
Evatanepag (0.3-3.0 mg/kg, directly injected into the marrow cavity of the tibia) promotes bone formation in rats[1].
Evatanepag (0.3, 3.0 mg/kg, intranasal administration, from day1 to day4) reduces HDM aeroallergen-induced increased RL response to methacholine in mice[2].
Evatanepag (1 mg/kg, intravenous injection) demonstrates high i.v. clearance (Cl: 56 mL/min/kg) and a short half-life (t1/2: 0.33 h)[1].
| Animal Model: | Rats[1] |
| Dosage: | 0.3, 1.0, 3.0 mg/kg |
| Administration: | Directly injected into the marrow cavity of the tibia |
| Result: | Dose-dependently increased in bone area, bone mineral content, bone mineral density. |
| Animal Model: | HDM (house dust mite)-sensitized BALB/c mice[2] |
| Dosage: | 0.3 mg/kg, 3 mg/kg |
| Administration: | Intranasal administration, from day1 to day4 |
| Result: | Prevented aeroallergen-driven increased RL (lung resistance) at 0.3 mg/kg. Prevented the enhanced MC activity by approximately 48% at 3 mg/kg. |
IC 50
EP2
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acidSupplier
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