ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > DNA damage > PARP inhibitors > AZD2461
AZD2461
AZD2461 Basic information
- Product Name:
- AZD2461
- Synonyms:
-
- 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
- 4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone
- CS-739
- AZD2461
- 4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one
- 1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-
- AZD 2461, >=98%
- AZD2461 USP/EP/BP
- CAS:
- 1174043-16-3
- MF:
- C22H22FN3O3
- MW:
- 395.43
- Product Categories:
-
- Inhibitors
- Inhibitor
- Mol File:
- 1174043-16-3.mol
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AZD2461 Chemical Properties
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥45.2 mg/mL in EtOH with ultrasonic
- form
- powder
- pka
- 12.07±0.40(Predicted)
- color
- white to beige
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AZD2461 Usage And Synthesis
Uses
4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one is a phthalazinone derivative and potential PARP inhibitor.
Biochem/physiol Actions
AZD2461, an olaparib analog, is an orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters. AZD2461 exhibits a high efficacy in olaparib-resistant tumors that overexpress P-glycoprotein.
storage
Store at -20°C
AZD2461Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
UHN Shanghai Research & Development Co., Ltd.
- Tel
- 021-58958002 18930822973
- SALES@UHNSHANGHAI.COM