Basic information Safety Supplier Related

H-TYR-TYR-OH

Basic information Safety Supplier Related

H-TYR-TYR-OH Basic information

Product Name:
H-TYR-TYR-OH
Synonyms:
  • tyrosyltyrosine
  • H-TYR-TYR-OH
  • TYR-TYR
  • TYR-TYR CRYSTALLINE
  • (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
  • (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propionic acid
  • (2S)-2-[[(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
  • L-TYROSYL-L-TYROSINE
CAS:
1050-28-8
MF:
C18H20N2O5
MW:
344.36
Mol File:
1050-28-8.mol
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H-TYR-TYR-OH Chemical Properties

Melting point:
300 °C (decomp)
Boiling point:
703.1±60.0 °C(Predicted)
Density 
1.372±0.06 g/cm3(Predicted)
storage temp. 
-15°C
pka
pK1:3.52(+1);pK2:7.68(0);pK3:9.80(+1);pK4:10.26(+2) (25°C)
form 
Solid
color 
White to off-white
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H-TYR-TYR-OH Usage And Synthesis

Uses

H-TYR-TYR-OH (cas# 1050-28-8) is an antihypertensive peptide with angiotensin I-converting enzyme (ACE) inhibitory activity prepared from the powder of the jellyfish.

Definition

ChEBI: Tyrosyltyrosine in which each tyrosine residue has L-configuration.

in vivo

H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo[1]. H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats[1].

Animal Model:Anesthetized male SpragueDawley rats[1]
Dosage:12.5 mg/kg
Administration:Intraarterial injection; 12.5 mg/kg once
Result:Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration.
Animal Model:Spontaneously hypertensive rats[1]
Dosage:0, 50 and 100 mg/kg
Administration:Intraperitoneal injection; once
Result:Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.

H-TYR-TYR-OHSupplier

GL Biochem (Shanghai) Ltd
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Shanghai Hanhong Scientific Co.,Ltd.
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Chemsky (shanghai) International Co.,Ltd
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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BOC Sciences
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1-631-485-4226; 16314854226
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