5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride
5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Basic information
- Product Name:
- 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride
- Synonyms:
-
- 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride
- 5,6,7,8-TETRAHYDRO-1,7-NAPHTHYRIDINE HCL
- 1,7-Naphthyridine, 5,6,7,8-tetrahydro- (hydrochloride)
- CAS:
- 1338707-67-7
- MF:
- C8H11ClN2
- MW:
- 170.63934
- Mol File:
- 1338707-67-7.mol
5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Chemical Properties
- storage temp.
- Inert atmosphere,Room Temperature
5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Usage And Synthesis
Uses
5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
5,6,7,8-Tetrahydro-[1,7]napthyridine hydrochloride. A methanolic solution (25 mL) of 7-Benzyl-5,6,7,8-tetrahydro-[1,7]naphthyridine (J. Het. Chem. 2001, 38, 535) (1.5g, 6.69 mmol) was degassed with argon for 20 min followed by the addition of 4N HCl in dioxane (2 mL) and Pd/C (300 mg, 20 wt%) and stirred under 50 psi hydrogen pressure at room temperature for 24h. After completion of the reaction the mixture was filtered on a short pad of celite and washed with methanol (4 × 25 mL). The filtrate was evaporated to dryness in vacuo and crystallized from methanol. Yield: 65% (calculated as 2HCl salt), 900 mg, yellowish solid.
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