Lascufloxacin
Lascufloxacin Basic information
- Product Name:
- Lascufloxacin
- Synonyms:
-
- KRP-AM1977X
- 3-Quinolinecarboxylic acid, 7-[(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoro-1-pyrrolidinyl]-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-8-methoxy-4-oxo-
- KRP-AM1977
- Lascufloxacin
- CAS:
- 848416-07-9
- MF:
- C21H24F3N3O4
- MW:
- 439.43
- Product Categories:
-
- API
- Mol File:
- 848416-07-9.mol
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Lascufloxacin Chemical Properties
- Boiling point:
- 637.0±55.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- solubility
- Chloroform (Slightly), DMSO (Very Slightly)
- form
- Solid
- pka
- 6.29±0.50(Predicted)
- color
- White to Off-White
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Lascufloxacin Usage And Synthesis
Uses
Lascufloxacin is an intermediate used in the preparation of quinolonecarboxylic acid deriatives as antibacterial agents.
in vivo
A pharmacodynamic study using a mouse thigh infection model indicates that the ratios of the free area under the curve (fAUC) to MIC in plasma required for bacteriostasis, or 1-log or 2-log CFU killing against S. pneumoniae isolates, are 10, 16, and 28, respectively. Lascufloxacin shows significant bacterial killing in the mouse model when emulated the area under the concentration-time curve (AUC) in plasma in dose of 75 mg per day [q.d.]) [2].
IC 50
Quinolone
LascufloxacinSupplier
Moltt Biocem Co., Ltd.
- Tel
- +86-21-38682181 15900741819
Jinan Yaoyan Pharmaceutical Co., Ltd.
- Tel
- jnyaoyan@163.com
Changzhou Yongfeng Biomedicine Co. Ltd.
- Tel
- 15006117673
- 2973592490@qq.com
Nanjing Kanglirui Biotechnology Co., Ltd.
- Tel
- +86-18626219813
- 812493095@qq.com
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
- Tel
- meitaochem@126.com
- meitaochem@126.com