Fmoc-3VVD-OH Chemical Properties

Boiling point:

793.0±60.0 °C(Predicted)

Density 

1.144±0.06 g/cm3(Predicted)

solubility 

DMSO: ≥ 37 mg/mL (58.01 mM)

pka

4.08±0.10(Predicted)

form 

Solid

color 

White to off-white

Water Solubility 

Water: < 0.1 mg/mL (insoluble)

InChIKey

JDMOCVJBADMSJP-FCUBIXSHSA-N

SMILES

C(NC(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C)(=O)[C@H](C(C)C)N([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C

Fmoc-3VVD-OH Usage And Synthesis

Description

Fmoc-3vvd-OH, chemically known as (5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-methoxy-4,10-dimethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid, is an antibody-drug conjugate (ADC) linker. Fmoc-3vvd-OH is also an intermediate in the synthesis of MMAE. The Fmoc protecting group can be removed with a base (usually piperidine) to reveal the methylated N-terminus of the peptide.

Uses

Fmoc-3VVD-OH is a cleavable ADC linker for antibody-drug conjugate (ADC) synthesis.

Biological Activity

Fmoc-3VVD-OH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

in vivo

ADCs consist of antibodies linked to ADC cytotoxins through ADC linkers.

target