Potassium citrate monohydrate Chemical Properties

Melting point:

275 °C (dec.)(lit.)

Density 

1.98

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H₂O: 1 M at 20 °C, clear, colorless

form 

Granular

Specific Gravity

1.98

color 

White crystalline

Odor

Odorless

PH Range

8 - 9.5

PH

7.5-9.0 (25℃, 50mg/mL in H2O)

Water Solubility 

Soluble in water and glycerol. Practically insoluble in alcoholSoluble in water and glycerol. Insoluble in alcohol

Merck 

14,7623

BRN 

3924344

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

PJAHUDTUZRZBKM-UHFFFAOYSA-K

CAS DataBase Reference

6100-05-6(CAS DataBase Reference)

EPA Substance Registry System

Tripotassium citrate monohydrate (6100-05-6)

Safety Information

Hazard Codes 

F,T,C,Xi

Risk Statements 

22-35

Safety Statements 

26-36/37/39-45-24/25

WGK Germany 

1

F 

3

TSCA 

Yes

HS Code 

29181500

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Potassium citrate monohydrate Usage And Synthesis

Chemical Properties

White/clear crystalline powder

Chemical Properties

Transparent prismatic crystals or a white, granular powder. Potassium citrate is hygroscopic and odorless, and has a cooling, saline taste.

Uses

Potassium Citrate, Monohydrate is a sequestrant and buffer that exists as crystals or powder. it is slightly hygroscopic and possesses the advantageous properties of citric acid without having its acid reaction. a 1% solution has a ph of 7.5–9.0. it reacts with metal ions such as calcium, magnesium, and iron to form a complex. it is soluble in water with a solubility of 1.8 g in 1 ml of 20°c water and 2 g in 1 ml of 80°c water. it is found in artificially sweetened jelly and in certain milk and meat products. uses include processed cheese, pud- dings, and dietetic foods in which sodium is undesirable. it is also termed tripotassium citrate.

Uses

In foods and beverages as buffering, sequestering or emulsifying agent.

Uses

Tripotassium Citrate Monohydrate is used in manufacturing method of printed circuit board for autonomous vehicle to perform recognition, judgment, determination and execution.Citric acid is a weak organic acid that is known as a commodity chemical, as more than a million tonnes are produced every year by mycological fermentation on an industrial scale using crude sugar solutions, such as molasses and strains of Aspergillus niger. Citric acid is widely distributed in plants and in animal tissues and fluids and exist in greater than grace amounts in variety of fruits and vegetables, most notably in citrus fruits such as lemon and limes. Citric acid is mainly used as an acidifier, flavoring agent and chelating agent. Citric acid is also a metabolite of Dimethyl Fumarate (D464965), a compound

Production Methods

Potassium citrate is prepared by adding either potassium bicarbonate or potassium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is then filtered and evaporated to dryness to obtain potassium citrate.

Definition

ChEBI: A hydrate that is the monohydrate form of potassium citrate.

General Description

Potassium citrate tribasic monohydrate (KCTM) is a potassium salt that has been reported to be efficient in forming aqueous two-phase system (ATPS) with UCON 50-HB-5100, a random copolymer. This product is a high quality pharmacopoeia product that meets the testing specifications of USP (United States Pharmacopoeia). It can be employed in research and pilot studies.

Pharmaceutical Applications

Potassium citrate is used in beverages, foods, and oral pharmaceutical formulations as a buffering and alkalizing agent. It is also used as a sequestering agent and as a therapeutic agent to alkalinize the urine and to relieve the painful irritation caused by cystitis.

Biochem/physiol Actions

Potassium citrate can be used to prepare citrate water that supports the survival of streptozotocin (STZ)-diabetic mice. It might reduce the successive stone formation in calcium nephrolithiasis. Potassium citrate serves as an activator for producing activated carbons.

Side effects

The most common side effects of potassium citrate are gastrointestinal. Potassium citrate can be irritating to the stomach. Potassium citrate may cause an upset stomach, nausea or vomiting, and diarrhea or loose stools.

Safety

Potassium citrate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material by this route of administration.
Most potassium citrate safety data relate to its use as a therapeutic agent, for which up to 10 g may be administered daily, in divided doses, as a treatment for cystitis. Although there are adverse effects associated with excessive ingestion of potassium salts, the quantities of potassium citrate used as a pharmaceutical excipient are insignificant in comparison to those used therapeutically.
(IV, dog): 0.17 g/kg

storage

Potassium citrate is a stable, though hygroscopic material, and should be stored in an airtight container in a cool, dry place. It is deliquescent in moist air.

Purification Methods

It solubility in H2O is 154% and it loses H2O at 180o. [Beilstein 3 III 1091.]

Incompatibilities

Aqueous potassium citrate solutions are slightly alkaline and will react with acidic substances. Potassium citrate may also precipitate alkaloidal salts from their aqueous or alcoholic solutions. Calcium and strontium salts will cause precipitation of the corresponding citrates. Potassium citrate is incompatible with strong oxidizing agents.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral solutions and suspensions; topical emulsions and aerosol foams). Included in nonparenteral medicines (cutaneous foams and emulsions; oral liquids, granules, mixtures and soluble tablets; topical liquids, emulsions and mousses) licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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