Verinurad Chemical Properties

Melting point:

204 - 207°C

Boiling point:

566.7±50.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

2.91±0.10(Predicted)

form 

Solid

color 

Off-White to Pale Brown

Verinurad Usage And Synthesis

Description

Verinurad is an inhibitor of urate anion transporter 1 (URAT1; IC₅₀ = 0.025 μM for the human transporter). It is selective for human URAT1 over rat URAT1 (IC₅₀ = 41 μM), as well as human organic anion transporter 1 (OAT1) and OAT4 (IC₅₀s = 4.6 and 5.9 μM, respectively).

Uses

Verinurad is a second generation selective uric acid reabsorption inhibitor.

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