2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE Chemical Properties

Melting point:

84-85 °C(Solv: benzene (71-43-2))

Boiling point:

452.0±35.0 °C(Predicted)

Density 

1.257±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

15.30±0.40(Predicted)

Appearance

Off-white to light yellow Solid

CAS DataBase Reference

186685-89-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2912490090

2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-(4-formyl-2-methoxyphenyl)acetamide from vanillin and chloroacetamide: In a solvent mixture of acetonitrile-DMF (20 mL, 8:2, v/v), chloroacetamide (0.010 mol), vanillin (0.011 mol), and potassium carbonate (2.00 g, 0.0145 mol) were sequentially added. The reaction mixture was heated and refluxed under stirring for 5-7 h. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solvent was removed by evaporation, the residue was treated with an appropriate amount of water and the precipitated solid was collected by filtration. The resulting precipitate was washed with 30% aqueous methanol and subsequently dried in air. The yield of the product 2-(4-formyl-2-methoxyphenyl)acetamide and its physicochemical properties are listed in Table 9.

References

[1] Russian Chemical Bulletin, 2015, vol. 64, # 2, p. 395 - 404
[2] Izv. Akad. Nauk, Ser. Khim., 2015, # 2, p. 395 - 404,10
[3] Russian Journal of General Chemistry, 2005, vol. 75, # 7, p. 1113 - 1124
[4] European Journal of Medicinal Chemistry, 2014, vol. 81, p. 1 - 14

2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE(186685-89-2)Related Product Information

• 2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE
• 2-(4-FORMYL-2-METHOXY-PHENOXY)-N-PHENYL-ACETAMIDE
• 2-(4-FORMYL-2-METHOXY-PHENOXY)-N-O-TOLYL-ACETAMIDE
• 2-(4-FORMYL-2-METHOXY-PHENOXY)-N-(4-METHOXY-PHENYL)-ACETAMIDE
• 2-(4-FORMYL-2-METHOXY-PHENOXY)-N-P-TOLYL-ACETAMIDE
• 2-(4-FORMYL-2-METHOXY-PHENOXY)-N-M-TOLYL-ACETAMIDE
• N-(4-BROMO-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE
• 2-(2-ETHOXY-4-FORMYL-PHENOXY)-N-P-TOLYL-ACETAMIDE
• 3-METHOXY-4-(2-MORPHOLIN-4-YL-2-OXO-ETHOXY)-BENZALDEHYDE
• N-CYCLOHEXYL-2-(2-ETHOXY-4-FORMYLPHENOXY)ACETAMIDE
• N-(4-CHLORO-2-METHOXY-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE
• N-(2-CHLORO-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE
• N-(3-CHLORO-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE
• TIMTEC-BB SBB001026
• TIMTEC-BB SBB004796
• 3-METHOXY-4-(2-OXO-2-PIPERIDIN-1-YL-ETHOXY)-BENZALDEHYDE
• 2-(2-ETHOXY-4-FORMYL-PHENOXY)-N-PHENYL-ACETAMIDE
• 2-(4-FORMYL-2-METHOXYPHENOXY)ACETIC ACID, N-(2-BIPHENYLYL)AMIDE