8-(tert-Butoxy)-8-oxooctanoic acid Chemical Properties

Boiling point:

324.8±25.0 °C(Predicted)

Density 

1.024±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

4.76±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

InChI

InChI=1S/C12H22O4/c1-12(2,3)16-11(15)9-7-5-4-6-8-10(13)14/h4-9H2,1-3H3,(H,13,14)

InChIKey

BONUHUQZCZQQEN-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)CCCCCCC(O)=O

8-(tert-Butoxy)-8-oxooctanoic acid Usage And Synthesis

Uses

8-(tert-butoxy)-8-oxooctanoic acid can be used as an intermediate in the production of complex organic molecules.

Synthesis

The general procedure for the synthesis of 8-(tert-butoxy)-8-oxooctanoic acid from octanedioic acid and tert-butanol was as follows: octanedioic acid (1.00 g, 5.75 mmol), 2-methyl-2-propanol (6.9 mL, 71.8 mmol), EDCI (1.1 g, 5.74 mmol) and DMAP (0.7 g, 5.74 mmol) were dissolved in dichloromethane ( 6.8 mL). The reaction mixture was stirred at room temperature for 5 hours. After completion of the reaction, the reaction mixture was diluted with ether (60 mL) and washed sequentially with 0.01 N HCl (50 mL) and water (50 mL). The organic phase was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography with the eluent being 1:1 ethyl acetate:petroleum ether to afford 8-(tert-butoxy)-8-oxooctanoic acid (0.41 g, 1.77 mmol, 31% yield) as a colorless oil.1H NMR (400 MHz, DMSO-d6) δ ppm: 11.94 (broad single peak, 1H), 2.18 (double peak, J = 14.6, 7.3 Hz, 4H), 1.54-1.42 (multiple peaks, 4H), 1.40 (single peak, 9H), 1.34-1.20 (multiple peaks, 4H).

References

[1] Patent: WO2017/212329, 2017, A1. Location in patent: Page/Page column 30; 83; 84
[2] Chemistry and Physics of Lipids, 2002, vol. 119, # 1-2, p. 51 - 68
[3] Chemical Communications, 1999, # 9, p. 823 - 824

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