Basic information Safety Supplier Related

ACT-246475

Basic information Safety Supplier Related

ACT-246475 Basic information

Product Name:
ACT-246475
Synonyms:
  • ACT-246475
  • ((R)-3-(4-(butoxycarbonyl)piperazin-1-yl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carboxamido)-3-oxopropyl)phosphonic acid(WXG03500)
  • Selatogrel
  • 1-Piperazinecarboxylic acid, 4-[(2R)-2-[[[6-[(3S)-3-methoxy-1-pyrrolidinyl]-2-phenyl-4-pyrimidinyl]carbonyl]amino]-1-oxo-3-phosphonopropyl]-, 1-butyl ester
  • ((R)-3-(4-(butoxycarbonyl)piperazin-1-yl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carboxamido)-3-oxopropyl)phosphonic acid
CAS:
1159500-34-1
MF:
C28H39N6O8P
MW:
618.62
Mol File:
1159500-34-1.mol
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ACT-246475 Chemical Properties

Density 
1.40±0.1 g/cm3(Predicted)
form 
Solid
pka
1.38±0.10(Predicted)
color 
Light yellow to yellow
InChIKey
FYXHWMQPCJOJCH-GMAHTHKFSA-N
SMILES
N1(C(OCCCC)=O)CCN(C(=O)[C@@H](NC(C2C=C(N3CC[C@H](OC)C3)N=C(C3=CC=CC=C3)N=2)=O)CP(O)(O)=O)CC1
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ACT-246475 Usage And Synthesis

Uses

((R)-3-(4-(butoxycarbonyl)piperazin-1-yl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carboxamido)-3-oxopropyl)phosphonic Acid is a useful research chemical compound used in the preparation of P2Y12 Receptor Antagonists.

in vivo

Selatogrel (0-0.1 mg/kg, i.v., single dosage) dose-dependently blocks thrombus formation in the wistar rat FeCl3 model and causes less surgical blood loss[1].

Animal Model:FeCl3 induced arterial injury in wistar rats[1]
Dosage:0-0.1 mg/kg
Administration:i.v., 5 minutes before arterial injury
Result:Prevented the FeCl3-induced thrombotic occlusions in a dose-dependent manner with minimal observed surgical blood loss of 0.4 g.

ACT-246475Supplier

Taizhou Zhongzhi Biotechnology Co., Ltd Gold
Tel
13012344321
Email
3995296515@qq.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Hefei TianRui Pharmaceutical Chemistry Co., Ltd.
Tel
0551-68933033 13956024211
Email
trchem@163.com
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Email
tcy@tcypharm.com
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com