7-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE HYDROCHLORIDE Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

7-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE HYDROCHLORIDE Usage And Synthesis

Synthesis

7-Methoxyindan-1-one oxime (2.92 g, 16 mmol) was dissolved in acetic acid (150 mL) and the hydrogenation reaction was carried out using an H-cube hydrogenation reactor under the following conditions set at a flow rate of 1 mL/min, a temperature of 80 °C, a pressure of 100 bar, and a catalyst of 10% Pd/C. Upon completion of the reaction, the solvent in the reaction mixture was removed by evaporation and the residue was dissolved in methanol, followed by the addition of 1 equiv. of hydrochloric acid in methanol. The solvent was evaporated again and the resulting residue was ground with ether to give 7-methoxy-1-aminoindan hydrochloride (2.38 g, 12 mmol, 75% yield). Electrospray mass spectrometry (ESMS) showed m/z 147 ([M + H]+).

References

[1] Patent: WO2010/71846, 2010, A2. Location in patent: Page/Page column 160

7-METHOXY-2,3-DIHYDRO-1H-INDEN-1-AMINE HYDROCHLORIDE(1187160-18-4)Related Product Information

• 7-METHOXY-3,3-DIMETHYL-2,3-DIHYDRO-1H-INDEN-1-ONE
• 7-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE
• 7-methoxy-2,3-dihydro-1H-inden-1-amine
• 7-METHOXY-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE
• 7-METHOXY-1-INDANECARBOXYLIC ACID
• (R)-2-AMINO-3-(4-FLUOROPHENYL)PROPAN-1-OL HYDROCHLORIDE
• 1-(2-FLUORO-5-METHOXYPHENYL)ETHAN-1-AMINE HYDROCHLORIDE
• (R)-1-(3-Fluoro-4-Methoxyphenyl)ethanaMine hydrochloride
• (1S)-1-(4-FLUORO-3-METHYLPHENYL)ETHYLAMINE-HCl
• (R)-2-(5-fluoro-2-methoxyphenyl)pyrrolidine hydrochloride
• 3-(DIFLUOROMETHYL)-4-FLUOROANILINE HYDROCHLORIDE
• (2S)-2-AMINO-2-(4-FLUORO-2-METHYLPHENYL)ETHAN-1-OL HYDROCHLORIDE
• (S)-3-AMINO-3-CYCLOPENTYLPROPANOIC ACID HYDROCHLORIDE