TYK2-IN-2 Chemical Properties

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 25 mg/mL (80.55 mM)

form 

Solid

pka

12.63±0.50(Predicted)

color 

White to off-white

TYK2-IN-2 Usage And Synthesis

Uses

TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC50s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC50 of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases[1].

IC 50

Tyk2 JH2: 7 nM (IC₅₀); PDE4: 62 nM (IC₅₀)

References

[1] Moslin R, et al. Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm. 2016 Dec 15;8(4):700-712. DOI:10.1039/c6md00560h