ABBV-2222 (GLPG2222) Chemical Properties

Boiling point:

701.1±60.0 °C(Predicted)

Density 

1.56±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 50 mg/mL (89.37 mM; Need ultrasonic)

pka

4.16±0.10(Predicted)

form 

Solid

color 

White to off-white

InChIKey

QVDYQHXNAQHIKH-TZIWHRDSSA-N

SMILES

C(O)(=O)C1=CC=C([C@@H]2OC3=CC(OC(F)F)=CC=C3[C@H](NC(C3(C4=CC=C5OC(F)(F)OC5=C4)CC3)=O)C2)C=C1

ABBV-2222 (GLPG2222) Usage And Synthesis

Uses

Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research[1].

in vivo

References

[1] Xueqing Wang, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator DOI:10.1021/acs.jmedchem.7b01339
[2] Ashvani K Singh, et al. Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222. J Pharmacol Exp Ther. 2020 Jan;372(1):107-118. DOI:10.1124/jpet.119.261800