LDC-3140 (LDC043140)
LDC-3140 (LDC043140) Basic information
- Product Name:
- LDC-3140 (LDC043140)
- Synonyms:
-
- LDC-3140 (LDC043140)
- LDC 3140
- LDC043140
- LDC3140
- LDC-3140
- Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[[2-(dimethylamino)phenyl]methyl]-8-(1-methylethyl)-2-[(1-methyl-4-piperidinyl)oxy]-
- CAS:
- 1453833-30-1
- MF:
- C23H33N7O
- MW:
- 423.55
- Mol File:
- 1453833-30-1.mol
LDC-3140 (LDC043140) Chemical Properties
- Density
- 1.23±0.1 g/cm3(Predicted)
- pka
- 7.84±0.10(Predicted)
LDC-3140 (LDC043140) Usage And Synthesis
Description
LDC3140, also known as LDC043140, is a potent CDK7 inhibitor. Cyclin-dependent kinase 7 (CDK7) activates cell cycle CDKs and is a member of the general transcription factor TFIIH. Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.
Uses
LDC3140 is a selective CDK7 inhibitor (IC50<5 nM). By inhibiting the activity of CDK7, LDC3140 affects the regulation of the cell cycle, leading to cell cycle arrest and thus inhibiting the proliferation of tumor cells. LDC3140 can be used in the research of cancer treatment[1].
IC 50
CDK7: <5 nM (IC50)
References
[1] H Liang, et al. Recent progress in development of cyclin-dependent kinase 7 inhibitors for cancer therapy. Expert Opinion on Investigational Drugs 30.1 (2021): 61-76. DOI:10.1080/13543784.2021.1850693