LDC-3140 (LDC043140)
LDC-3140 (LDC043140) Basic information
- Product Name:
- LDC-3140 (LDC043140)
- Synonyms:
-
- LDC-3140 (LDC043140)
- LDC 3140
- LDC043140
- LDC3140
- LDC-3140
- Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[[2-(dimethylamino)phenyl]methyl]-8-(1-methylethyl)-2-[(1-methyl-4-piperidinyl)oxy]-
- CAS:
- 1453833-30-1
- MF:
- C23H33N7O
- MW:
- 423.55
- Mol File:
- 1453833-30-1.mol
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LDC-3140 (LDC043140) Chemical Properties
- Density
- 1.23±0.1 g/cm3(Predicted)
- pka
- 7.84±0.10(Predicted)
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LDC-3140 (LDC043140) Usage And Synthesis
Description
LDC3140, also known as LDC043140, is a potent CDK7 inhibitor. Cyclin-dependent kinase 7 (CDK7) activates cell cycle CDKs and is a member of the general transcription factor TFIIH. Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.