Neostigmine Iodide Chemical Properties

Melting point:

167 °C

Neostigmine Iodide Usage And Synthesis

Description

Neostigmine Iodide is a parasympathomimetic compound that acts as a reversible acetylcholinesterase inhibitor. It is used to improve muscle tone in people with myasthenia gravis and routinely in anesthesia to reverse the effects of non-depolarizing muscle relaxants such as rocuronium and vecuronium at the end of an operation, usually in a dose of 25 to 50 μg per kilogram. It can also be used for urinary retention resulting from general anesthesia and to treat curariform drug toxicity.

Uses

Neostigmine iodide is a reversible acetylcholinesterase inhibitor with muscle tone-enhancing activity. Neostigmine iodide is primarily used to improve muscle function in patients with myasthenia gravis. Neostigmine iodide is also used in routine anesthesia to reverse the effects of nondepolarizing muscle relaxants such as rocuronium[1].

References

[1] Reversal of neuromuscular blockade with sugammadex or neostigmine/atropine: Effect on postoperative gastrointestinal motility DOI:10.1016/j.jclinane.2016.03.010