N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos Chemical Properties

Boiling point:

690.3±65.0 °C(Predicted)

Density 

1.259±0.06 g/cm3(Predicted)

N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos Usage And Synthesis

Description

N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos is a PEG linker containing tosyl, boc and aminoxy moieties. Tosyl is a good leaving group and can also act as an alcohol protecting group in organic synthesis. The t-Boc protecting group can be removed under acidic conditions which allows for the amine group to be further reacted. The hydrophilic PEG linker increases the water solubility of the compound to further enhance the water solubility of the compound in aqueous media.

Uses

Tos-aminoxy-Boc-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005