1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Basic information
- Product Name:
- 1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene
- Synonyms:
-
- 1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene
- 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
- NSC 636819
- Benzene, 1,5-bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitro-
- KDM4A/KDM4B Inhibitor, NSC636819
- CAS:
- 1618672-71-1
- MF:
- C22H12Cl4N2O4
- MW:
- 510.15
- Mol File:
- 1618672-71-1.mol
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1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Chemical Properties
- Boiling point:
- 625.5±55.0 °C(Predicted)
- Density
- 1.558±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Yellow to orange
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1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene Usage And Synthesis
Uses
NSC 636819 is a novel and selective KDM4A/KDM4B inhibitor that induces apoptosis in cultured prostate cancer cells.
Biological Activity
Cell permeable: yes', 'Primary Target
KDM4A/B', 'Reversible: yes
in vivo
NSC636819 (C-4) (20 or 40 mg/kg; ip; 5 times a week; 4 weeks) strongly suppresses A549 tumor growth and sensitizes tumors to TRAIL-inducer ONC201 in mouse model[2].
| Animal Model: | A549 Lung cancer xenograft model in mice[2] |
| Dosage: | 20 mg/kg, 40 mg/kg |
| Administration: | ip; 5 times per weeks, 27 days; with or without ONC201 (i.p.; 25?mg/kg, 1 time a week). |
| Result: | Dose-dependently inhibited the tumor growth, and sensitized tumors to TRAIL. Induced tumor expression of TRAIL, DR5 and the level of cleaved caspase-7 and H3K9me3, whereas decreased the expression of KDM4A in xenograft tumors. |
IC 50
KDM4
storage
Store at +4°C
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzeneSupplier
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