OSS-128167
OSS-128167 Basic information
- Product Name:
- OSS-128167
- Synonyms:
-
- OSS-128167;OSS 128167;OSS128167
- OSS-128167(SIRT6-IN-1)
- OSS-128167
- SIRT6-IN-1
- Benzoic acid, 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-
- 5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid
- SIRT6,deacetylase,OSS_128167,TNF-α,immune,antiviral,inhibit,PPARα,H3K9,Sirtuin,acetylation,anti-cancer,Hepatitis B virus,Inhibitor,diabetes,GLUT-1,chemosensitization,HBV
- OSS_128167, 10 mM in DMSO
- CAS:
- 887686-02-4
- MF:
- C19H14N2O6
- MW:
- 366.32
- EINECS:
- 604-604-1
- Product Categories:
-
- API
- Mol File:
- 887686-02-4.mol
OSS-128167 Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly)
- form
- Solid
- color
- Red to Very Dark Brown
- InChI
- InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26)
- InChIKey
- HTJWLEGCECXGSQ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(NC(=O)C2=CC=CC(NC(C3=CC=CO3)=O)=C2)=CC=C1O
OSS-128167 Usage And Synthesis
Uses
OSS_128167, is a selective SIRT6 inhibitor, showing immunosuppressive and chemosensitizing effects.
Uses
OSS_128167, is a selective SIRT6 inhibitor, showing immunosuppressive and chemosensitizing effects
Biological Activity
eCll penetrant, potent and selective inhibitor of SIRT6.
OSS_128167 is a cell penetrant, potent and selective inhibitor of SIRT6 (Sirtuin 6) th at exhibits anti-cancer, anti-inflammatory, and anti-viral properties. OSS_128167 inhibits HBV transcription and replication through upregulating peroxisome proliferator-activated receptors α (PPARα) expression.
in vivo
OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice[2].
| Animal Model: | Male HBV transgenic mice (6-8-week-old)[2] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; every 4 days; for 12 days |
| Result: | The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice. |
IC 50
SIRT6: 89 μM (IC50); SIRT2: 751 μM (IC50); SIRT1: 1578 μM (IC50); HBV
OSS-128167Supplier
- Tel
- 13621943973; 13621943973
- sales@jamxmpharmatech.com
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Tel
- 400-164-7117 13681763483
- product02@bidepharm.com
- Tel
- 15221275939
- shenlinxing@macklin.cn
- Tel
- 021-52996696，15000506266 15000506266