Fluo-2 AM
Fluo-2 AM Basic information
- Product Name:
- Fluo-2 AM
- Synonyms:
-
- Glycine, N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[4-[6-[(acetyloxy)methoxy]-3-oxo-3H-xanthen-9-yl]-2-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]phenyl]-, (acetyloxy)methyl ester
- CAS:
- 1070771-36-6
- MF:
- C51H52N2O23
- MW:
- 1060.96
- Mol File:
- 1070771-36-6.mol
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Fluo-2 AM Chemical Properties
- storage temp.
- -20°C
- form
- A solid
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Fluo-2 AM Usage And Synthesis
Biological Activity
Fluo-2 AM is a cell-permeable fluorescent calcium indicator.1,2 It has been used to measure the activity of the neuropeptide Y4 receptor, as well as to detect intracellular calcium in tetrandine-stimulated primary rabbit corpus cavernosum smooth muscle cells. It binds to calcium (Kd = 290 nM) and displays excitation/emission maxima of 490/515 nm, respectively. Fluo-2 AM is also available in a cell-impermeable form .
References
1.Sliwoski, G., Schubert, M., Stichel, J., et al.Discovery of small-molecule modulators of the human Y4 receptorPLoS One11(6)e0157146(2016) 2.Liu, J.-H., Chen, J., Wang, T., et al.Effects of tetrandrine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbitsAsian J. Androl.8(4)405-409(2006)
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Fluo-2 AM(1070771-36-6)Related Product Information
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