KW-6055
KW-6055 Basic information
- Product Name:
- KW-6055
- Synonyms:
-
- KW-6055
- Butanamide, N-[3-nitro-4-(2-pyridinylmethyl)phenyl]-
- KW6055,KW 6055
- CAS:
- 63233-46-5
- MF:
- C16H17N3O3
- MW:
- 299.32
- Mol File:
- 63233-46-5.mol
KW-6055 Usage And Synthesis
Uses
KW-6055 is a benzylpyridine derivative with anti-amnesic effects. KW-6055 can increase the level of ACh in the brain cholinergic system and stimulate cholinergic neurons.
in vivo
KW-6055 is a benzylpyridine derivative and has anti-amnesic activity. KW-6055 (40, 160 mg/kg, p.o.) increases the extracellular level of ACh in normal rats (257±23, 202±24%). In basal forebrain-lesioned rats, KW-6055 (40 mg/kg, p.o.) significantly increases the extracellular level of ACh (251±22%) for more than 2 hr, which is longer than in normal rats[1].
References
[1] Kurokawa M, et al. [Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems]. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43. Japanese. DOI:10.1254/fpj.99.435
[2] Kurokawa M, et al. Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43. DOI:10.1254/fpj.99.435
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