A-485
A-485 Basic information
- Product Name:
- A-485
- Synonyms:
-
- (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide
- A-485
- A485;A 485
- Spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide, N-[(4-fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-, (1R)-
- A-486
- N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide
- inhibit,HATs,A 485,Inhibitor,Epigenetic Reader Domain,Histone Acetyltransferase,HAT,A-485,A485
- N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide
- CAS:
- 1889279-16-6
- MF:
- C25H24F4N4O5
- MW:
- 536.48
- Product Categories:
-
- intermediate
- Mol File:
- 1889279-16-6.mol
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A-485 Chemical Properties
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:97.41(Max Conc. mg/mL);181.57(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);18.64(Max Conc. mM)
Ethanol:57.88(Max Conc. mg/mL);107.89(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.47(Max Conc. mM) - form
- A crystalline solid
- pka
- 14.07±0.46(Predicted)
- color
- White to off-white
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A-485 Usage And Synthesis
Uses
A-485 is potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). Displays > 1000-fold selectivity over closely related HATs. Suppresses proliferation in several hematological malignancies and AR+ prostate cancer cell lines in vitro. Inhibits tumor growth in a castration-resistant prostate cancer xenograft model. Orally bioavailable.
storage
Store at -20°C
A-485Supplier
ShangHai ChuanQian Chemcial Technique Centre Gold
- Tel
- 15869524721
- 3525679403@qq.com
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd Gold
- Tel
- 15317229551
- 15151849396@163.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai Synchem Pharma Co., ltd
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com