PDD 00017273 Chemical Properties

Boiling point:

733.9±70.0 °C(Predicted)

Density 

1.52±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 10 mg/ml

form 

A solid

pka

11.67±0.20(Predicted)

color 

White to light yellow

PDD 00017273 Usage And Synthesis

Uses

PDD 00017273 is used as a chemical probe against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacol. to olaparib.

Biological Activity

PDD00017273 is a potent and selective inhibitor of Poly(ADP-ribose) glycohydrolase (PARG), which catalyses hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) polymerases (PARPs). PARG has been shown to be involved in the repair of single strand DNA breaks. PDD00017273 is selective for PARG, with EC50 = 26 nM, compared to values of 30 μM for PARP1 and ARH3.', 'PDD00017273 is cell permeable in nature. It is used for specific killing of cells defective in certain homologous recombination (HR) proteins such as breast cancer gene 1/2 (BRCA1/2).

storage

Store at -20°C

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