6-BROMO-1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONE Chemical Properties

Melting point:

>350°

Boiling point:

189℃

Density 

1.837

Flash point:

68℃

storage temp. 

Sealed in dry,Room Temperature

pka

11.36±0.20(Predicted)

Appearance

White to gray Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HazardClass 

IRRITANT

HS Code 

2933399990

6-BROMO-1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONE Usage And Synthesis

Synthesis

To a solution of 2,3-diamino-5-bromopyridine (5 g, 27 mmol) in tetrahydrofuran (THF, 87 mL) was added N,N'-carbonyl diimidazole (CDI, 3.02 g, 18.6 mmol). The reaction mixture was stirred at 80 °C for 16 hours. Upon completion of the reaction, water was added to quench the reaction and the mixture was filtered. The solid product was collected, washed sequentially with water and ether (Et2O), and dried under vacuum to afford 6-bromo-1H-imidazo[4,5-B]pyridin-2(3H)-one (5.3 g, 25 mmol, 93% yield), and the product could be used in subsequent reactions without further purification. Mass spectrometry (ESI) analysis: calculated value (C6H4BrN3O) 212.95; measured value, 214 [M + H]+.

References

[1] Patent: WO2018/67786, 2018, A1. Location in patent: Page/Page column 106
[2] Patent: WO2010/121164, 2010, A2. Location in patent: Page/Page column 61
[3] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 104-105

6-BROMO-1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONE(148038-83-9)Related Product Information

• 2H-Pyrrolo[2,3-b]pyridin-2-one,6-broMo-1,3-dihydro-
• ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
• 3H-IMidazo[4,5-c]pyridine, 6-broMo-
• 6-Bromoindanone
• N-(5-BROMO-2-PYRIDINYL)-FORMAMIDE
• 6-BROMO-1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONE
• 2,3-Diamino-5-bromopyridine
• 1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE
• 3-Amino-5-bromopyridine