2-(4-METHYLPIPERAZINO)BENZALDEHYDE Chemical Properties

Melting point:

44 °C

Boiling point:

110

Density 

1.107±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

7.69±0.42(Predicted)

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

85803-62-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

36/37/38-36

Safety Statements 

26-36/37/39

Hazard Note 

Corrosive

2-(4-METHYLPIPERAZINO)BENZALDEHYDE Usage And Synthesis

Synthesis

General procedure: 2-fluorobenzaldehyde (20.0 mL, 189.9 mmol), 1-methylpiperazine (33.0 mL, 297.7 mmol) and potassium carbonate (40.0 g, 289.4 mmol) were dissolved in water (200 mL) and heated to reflux. After the reaction was completed, it was cooled to room temperature and the reaction mixture was extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the target product 2-(4-methylpiperazine)benzaldehyde (PP57, 38.6 g, 100%) as an orange oil. Its NMR hydrogen spectrum (CDCl3) data were as follows: δ 10.10 (s, 1H), 7.77 (dd, J = 7.9, 1.7 Hz, 1H), 7.51-7.48 (m, 1H), 7.10-7.06 (m, 2H), 3.11 (t, J = 4.6 Hz, 4H), 2.63 (br s, 4H), 2.36 (s, 3H) .

References

[1] Patent: WO2006/48727, 2006, A1. Location in patent: Page/Page column 83
[2] Patent: US2003/87914, 2003, A1
[3] Russian Chemical Bulletin, 2004, vol. 53, # 6, p. 1240 - 1247
[4] Chemical Communications, 2017, vol. 53, # 75, p. 10448 - 10451
[5] Synthesis, 1987, # 7, p. 641 - 645

2-(4-METHYLPIPERAZINO)BENZALDEHYDE(85803-62-9)Related Product Information

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