AC-VEID-CHO Chemical Properties

Boiling point:

914.6±65.0 °C(Predicted)

Density 

1.238±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

H₂O: 1 mg/mL

form 

powder

pka

4.20±0.10(Predicted)

color 

white

Water Solubility 

H2O: 1mg/mL

Safety Information

WGK Germany 

3

MSDS

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AC-VEID-CHO Usage And Synthesis

Uses

AC-VEID-CHO is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO also inhibits VEIDase activity an IC50 value of 0.49 μM. AC-VEID-CHO can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease[1].

Biological Activity

Cell permeable: yes', 'Primary Target
caspase-6', 'Product does not compete with ATP.', 'Reversible: yes

IC 50

Caspase 3: 13.6 nM (IC₅₀); Caspase-6: 16.2 nM (IC₅₀); Caspase-7: 162.1 nM (IC₅₀)

References

[1] Robert Mintzer, et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One. 2012;7(1):e30376. DOI:10.1371/journal.pone.0030376