CARBOSTYRIL 124 Chemical Properties

Melting point:

>275°C (dec.)

Boiling point:

417.6±45.0 °C(Predicted)

Density 

1.223±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

11.45±0.70(Predicted)

color 

Off-White to Light Beige

Appearance

Off-white to light beige solid

λmax

350 nm

EPA Substance Registry System

2(1H)-Quinolinone, 7-amino-4-methyl- (19840-99-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

CARBOSTYRIL 124 Usage And Synthesis

Description

Suitable as a laser dye. Dyes and metabolites.

Chemical Properties

Off-White to Tan Solid

Uses

Suitable as a laser dye

General Description

Carbostyril 124 (CS124) is a chromophore that can be used as a laser dye for sensitization and optical detection. It acts as an antenna molecule that facilitates the light absorption and enhances fluorescence efficiency.

Synthesis

GENERAL PROCEDURE: Isophthalamide (1.0 g, 9.3 mmol) was added to ethyl acetoacetate (1.2 eq, 2-3.6 g) and the mixture was heated to reflux for 20 hours. After completion of the reaction, the mixture was poured into ice (100 g) and the precipitate was collected by filtration. Purification by silica gel column chromatography (100-200 mesh, eluent methanol/chloroform, 1:99 v/v) afforded 7-amino-4-methylquinolin-2(1H)-one.

References

[1] Medicinal Chemistry Research, 2013, vol. 22, # 11, p. 5227 - 5235
[2] Medicinal Chemistry Research, 2010, vol. 19, # 2, p. 193 - 209
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 4, p. 1624 - 1638
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8712 - 8728
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1648 - 1653

CARBOSTYRIL 124(19840-99-4)Related Product Information

• 2-HYDROXY-4-METHYLQUINOLINE
• CARBOSTYRIL 124
• deoxynybomycin
• Carbostyril Maleimide
• CARBOSTYRIL 165
• Carbostyril 124 N-Carboxymethyl Methanethiosulfonate
• Carbostyril 124 N-Carboxyethyl Methanethiosulfonate
• Carbostyril 124 N-Carboxymethyl Chloride
• 1,2,3,8-tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one
• nybomycin
• AURORA KA-8030
• 7-AMINO-3,4,6-TRIMETHYL-1H-QUINOLIN-2-ONE
• AURORA KA-8035
• 7-AMINO-4-METHOXYMETHYL-6-METHYL-1H-QUINOLIN-2-ONE
• N-[4-(METHOXYMETHYL)-6-METHYL-2-OXO-1,2-DIHYDRO-7-QUINOLINYL]HEXANAMIDE
• 2,2,2-TRIFLUORO-N-[4-(METHOXYMETHYL)-6-METHYL-2-OXO-1,2-DIHYDRO-7-QUINOLINYL]ACETAMIDE
• N-[4-(METHOXYMETHYL)-6-METHYL-2-OXO-1,2-DIHYDRO-7-QUINOLINYL]CYCLOPROPANECARBOXAMIDE
• 3-METHOXY-N-[4-(METHOXYMETHYL)-6-METHYL-2-OXO-1,2-DIHYDRO-7-QUINOLINYL]BENZENECARBOXAMIDE