5-METHOXY-1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID Chemical Properties

Boiling point:

458.4±40.0 °C(Predicted)

Density 

1.459

storage temp. 

2-8°C

pka

3.21±0.30(Predicted)

Appearance

White to off-white Solid

Safety Information

Risk Statements 

20/21/22

Safety Statements 

36/37

HS Code 

29333990

5-METHOXY-1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

White to grey solid

Synthesis

GENERAL STEPS: To a stirred solution of ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate (1.3 mmol) in ethanol (12 mL) was added 2 M sodium hydroxide solution (1.7 mmol, 1.1 mL). The reaction mixture was heated to reflux for 1 h (for 5-methoxy-1H-pyrrolo[2,3-C]pyridine-2-carboxylic acid) or 2 h (for other derivatives). After completion of the reaction, the solvent was removed by evaporation. Water (10 mL) was added to the residue and the pH was adjusted with acetic acid to 4.0. The precipitate was collected by filtration and the resulting solid was dried in a desiccator to give the target product 5-methoxy-1H-pyrrolo[2,3-C]pyridine-2-carboxylic acid.

References

[1] Molecules, 2014, vol. 19, # 9, p. 13342 - 13357