(S)-3'-hydroxy Blebbistatin
(S)-3'-hydroxy Blebbistatin Basic information
- Product Name:
- (S)-3'-hydroxy Blebbistatin
- Synonyms:
-
- (S)-3'-hydroxy Blebbistatin
- -hydroxy Blebbistatin
- 4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-1-(3-hydroxyphenyl)-6-methyl-, (3aS)-
- 1,2,3,3aS-tetrahydro-3a-hydroxy-1-(3-hydroxyphenyl)-6-methyl-4H-pyrrolo[2,3-b]quinolin-4-one
- (3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
- CAS:
- 2097136-42-8
- MF:
- C18H16N2O3
- MW:
- 308.33
- Mol File:
- 2097136-42-8.mol
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(S)-3'-hydroxy Blebbistatin Chemical Properties
- Boiling point:
- 563.5±60.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 12.5 mg/ml
- form
- A crystalline solid
- pka
- 9.79±0.10(Predicted)
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(S)-3'-hydroxy Blebbistatin Usage And Synthesis
Uses
(S)-3'-Hydroxy blebbistatin is a myosin II inhibitor and is more water-soluble than Blebbistatin[1].
References
[1] Sigrid Verhasselt, et al. Discovery of (S)-3'-hydroxyblebbistatin and (S)-3'-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties. Org Biomol Chem. 2017 Mar 1;15(9):2104-2118. DOI:10.1039/c7ob00006e
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